贺耘，重庆大学药学院教授、博导、院长。领导参与了数十项创新药物研发项目，和团队成功推进了10余个药物进入临床研究。发表SCI论文100余篇，申请专利100余项，他引5000余次，H指数41。是多家生物技术公司和制药企业的创始人或顾问。
个人简历
2006-2008 罗氏研发中心 (中国) 有限公司药物化学高级总监
2008-2012 保诺科技 (北京) 有限公司高级副总裁首席科学官
2012-2014 百华协会 (The BayHelix Group) 理事
2012-现在 重庆大学创新药物研究中心教授、博导、主任
2016-现在 重庆大学药学院教授、博导、院长
教育背景
1981-1985 西南大学，获化学学士学位
1985-1988 兰州大学，获化学硕士学位（潘鑫复教授）
1988-1990 香港中文大学中化学系，攻读博士学位（黄乃正教授）
1990-1992 爱荷华州立大学，获化学硕士学位
1995-2000 斯克利普斯研究所，获有机化学博士学位
代表性文章
X. H. Yang, G. M. Shi, J. Guo, C. H. Wang, Y. He, “Exosome-Encapsulated Antibiotic Against Intracellular Infections of Methicillin-Resistant Staphylococcus Aureus (MRSA).” Int. J. Nanomed., 2018, 13, 8095-8104.
Z. H. Lin, X. B. Xu, S. Zhao, X. H. Yang, J. Guo, Q. Zhang, C. M. Jing, S. Chen and Y. He, “Total Synthesis and Antimicrobial Evaluation of Natural Albomycins against Clinical Pathogens.” Nat. Commun., 2018, 9, 3445.
B. Xu, Z. M. Yu, S. C. Xiang, Y. S. Li, S. L. Zhang, Y. He, “Rational Design of Mitochondria-targeted Pyruvate Dehydrogenase Kinase 1 Inhibitors with Improved Selectivity and Antiproliferative Activity.” Eur. J. Med. Chem., 2018, 155, 275-284.
S. L. Zhang, Y. He, K. Y. Tam, “Targeting Cancer Metabolism to Develop Human Lactate Dehydrogenase 5 (HLDH5) Inhibitors.” Drug Discovery Today, 2018, 23, 1407-1415.
N. Zhang, Z. M. Yu, X. H. Yang, P. Hu, Y. He, “Synthesis of Novel Ring-contracted Artemisinin Dimers with Potent Anticancer Activities”, Eur. J. Med. Chem., 2018, 150, 829-840.
A. Yesu, X. H. Yang, M. H. Zhou, P. R. Devi, S. L. Zhang, Z. Wang, Y. He, “Synthesis and Anticancer Activity Evaluation of Novel Azacalix[2]arene[2]pyrimidines.” Eur. J. Med. Chem., 2018, 151, 214-225.
P. R. Devi; N. Zhang; Z. M. Yu; Z. Wang; Y. He, “Total Synthesis of Kanamienamide.” J. Org. Chem., 2017, 82, 11262–11268.
B. Sreenivas, P. R. Devi, W. X. Li, C. H. Wang, J. Guo, Y. He, “A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G.” Org. Lett., 2017, 19, 4996–4999.
Q. Liu, P. Hu and Y. He, “Asymmetric Total Synthesis of Nannocystin A.” J. Org. Chem., 2017, 82, 9217–9222.
M.Q. Tang; P. Hu; Q. Zheng; N. Tirelli; X. H. Yang; Z. L. Wang; Y. F. Wang; Q. Tang; Y. He, “Polymeric Micelles with Dual Thermal and Reactive Oxygen Species (ROS)-Responsiveness for Inflammatory Cancer Cell Delivery.” J. Nanobiotechnology, 2017, 15, 39.
Q. Zheng, P. Hu, Q. Tang, M. Q. Tang, Z. L. Zang, P. L. Shao, Z. Wang, Y. He, “Dually Responsive Amphiphilic Block Copolymer with Oxidation-Responsiveness and Tuneable LCST Behaviours” Materials Letters. 2017, 201, 133-136.
Z. L. Zang, S. Zhao, S. Karnakanti, C. L. Liu, P. L. Shao and Y. He, “Catalytic Multisite-Selective Acetoxylation Reactions at sp2 vs sp3 C–H Bonds in Cyclic Olefins.” Org. Lett. 2016, 18, 5014–5017.
N. Qi, S. R. Allu, Z. L. Wang, Q. Liu, J. Guo, and Y. He, “Asymmetric Total Syntheses of Aetheramides and Their Stereoisomers: Stereochemical Assignment of Aetheramides.” Org. Lett. 2016, 18, 4718–4721.
R. S Reddy, C. Lagishetti, I. N. C Kiran, H. Y. You, and Y. He, “Transition-Metal-Free Cascade Synthesis of 4-Quinolones: Umpolung of Michael Acceptors via Ene Reaction with Arynes.” Org. Lett. 2016, 18, 3818–3821.
J. Guo, I. N. C Kiran, R. S Reddy, J. S. Gao, M. Q. Tang, Y. Y. Liu, and Y. He, “Synthesis of Carbazolequinones by Formal [3 + 2] Cycloaddition of Arynes and 2-Aminoquinones.” Org. Lett. 2016, 18, 2499–2502.
Y. He, P. K. Agarwal, I. N. C Kiran, R. C. Yu, B. Cao, C Zou, X. H. Zhou, H. C. Xu, B. Xu, L. Zhu, Y. Lan, K. C. Nicolaou, “Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones.” Chem. Eur. J. 2016, 22, 7696–7701.
J. C. Wong, G. Tang, X. Wu, C. Liang, Z. Zhang, L. Guo, Z. Peng, W. Zhang, X. Lin, Z. Wang, J. Mei, J. Chen,
S. Pan, N. Zhang, Y. Liu, M. Zhou, L. Feng, Weili Zhao, S. Li, C. Zhang, M. Zhang, Y. Rong, T. Jin, X. Zhang, S. Ren, Ying Ji, R. Zhao, J. She, Y. Ren, C. Xu, D. Chen, J. Cai, S. Shan, D. Pan, Z. Ning, X. Lu, T. Chen, Y. He, L. Chen. "Pharmacokinetic Optimization of Class-Selective Histone Deacetylase Inhibitors and Identification of Associated Candidate Predictive Biomarkers of Hepatocellular Carcinoma Tumor Response." J. Med. Chem. 2012, 55, 8903-8925.
G. Zhang, P. Ren, N.S. Gray, T. Sim, X. Wang, Y. Liu, J. Che, W. Dong, S.S. Tian, M.L. Sandberg, T.A. Spalding, R. Romeo, M. Iskandar, Z. Wang, M.H. Seidel, D.S. Karanewsky, Y. He, “Discovery of Pyrimidine Benzimidazoles as Src-family Selective Lck Inhibitors. Part II.” Bioorg. Med. Chem. Lett. 2009, 19, 6691.
B. Wu, K. Kuhen, T. N. Nguyen, D. Ellis, B. Anaclerio, X. He, K. Yang, D. Karanewsky, H. Yin, K. Wolff, K. Bieza, J. Caldwell, Y. He, "Synthesis and Evaluation of N-Aryl Pyrrolidinones as Novel Anti-HIV-1 Agents. Part 1." Bioorg. Med. Chem. Lett. 2006, 16, 3430-3433.
Y. He, J, Yang, B. Wu, D. Robinson, K. Sprankle, P.-P. Kung, K. Lowery, V. Mohan, S. Hofstadler, E. E. Swayze, R. Griffey, “Synthesis and Evaluation of Novel Bacterial rRNA-binding Benzimidazoles by Mass Spectrometry.” Bioorg. Med. Chem. Lett. 2004, 14, 695-699.
K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, F. Roschangar, F. Sarabia, S. Ninkovic, Z. Yang, “The Olefin Metathesis Approach to Epothilone A and Its Analogs.” J. Am. Chem. Soc. 1997, 119, 7960-7973.
荣誉及社会兼职
重庆市“百人计划”获得者
百华协会理事
研究领域
（1）抗菌与抗癌新药的设计与合成
（2）天然产物全合成及生物活性研究
（3）药物靶向传输
