李亦舟，1987年2月生。

     博士，教授，博士生导师

         

    E-mail：yizhouli@cqu.edu.cn

 

          2009年于北京大学化学与分子工程学院获学士学位，研究方向为过渡金属催化的惰性化学键转化。2014年于北京大学化学与分子工程学院获博士学位，研究方向为DNA模板控制的化学生物学研究。2014年-2017年，在瑞士苏黎世联邦理工大学（ETH Zürich）从事博士后研究工作，研究方向为基于DNA编码化合物库的药物研发。2017年9月，被重庆大学聘为 “百人计划”特聘研究员，2019年3月被重庆大学聘为教授。近几年来，以通讯作者或第一作者身份在包括Nat. Chem., J. Am. Chem. Soc., Angew. Chem. Int. Edit.等国际顶级杂志上发表多篇论文。2018年入选重庆市第九批“百人计划”，2019年入选国家特聘青年专家。

热忱欢迎有志于化学生物学与药学研究的

博士后、研究生和本科生加入课题组！

教育及工作经历

2019.03-至今     重庆大学药学院•创新药物研究中心，教授（博士生导师）

2017.09-2019.02 重庆大学药学院•创新药物研究中心，重庆大学“百人计划”特聘研究员（博士生导师）

2014.09-2017.08 瑞士苏黎世联邦理工大学（ETH），药学博士后，合作导师：Prof. Dario Neri

2009.09-2014.07 北京大学,有机化学专业，理学博士，导师：李笑宇研究员

2005.09-2009.07北京大学，化学专业，理学学士，导师：施章杰教授

研究领域

药学化学生物学，化学遗传学，有机化学，药物化学

1. 以核酸编码化合库（DNA-encoded library）筛选技术为手段的新药先导化合物研究；

2. 以核酸作为工具的化学生物学研究；

3. 对生物大分子的选择性化学修饰；

4. 活性小分子探针设计、合成及靶点识别。

主持在研科研项目

1. 国家自然科学基金青年项目（21907011）

2. 中组部“海外高层次人才引进计划” 青年项目（A类资助）

3. 中央高校学科交叉及团队培育专项（2019CDQYYX018）

4. 重庆市留学人员回国创新支持计划项目（cx2019084）
   

主持已结题科研项目

1. 重庆市留学人员回国创新支持计划项目（cx2018063）

2. 重庆市基础研究与前沿探索项目（cstc2018jcyjAX0517）

3. 重庆大学“百人计划”人才启动基金（0247001104406）
   

 

发表论文

1. Min Xi, Yizhou Li^*, and Jiang Zhou^*, Exploration of the formation and structure characteristics of a miR-92a promoter G-quadruplex by ESI-MS and CD. Talanta. 2020, 211: 120708

2. Guixian Zhao, Yiran Huang, Yu Zhou, Yizhou Li*, and Xiaoyu Li*, Future challenges with DNA-encoded chemical libraries in the drug discovery domain, Expert Opinion on Drug Discovery, 2019, 14, 735-753.

3. Natasa Savic, Femke CAS Ringnalda, Helen Lindsay, Christian Berk, Katja Bargsten, Yizhou Li, Dario Neri, Mark D Robinson, Constance Ciaudo, Jonathan Hall, Martin Jinek and Gerald Schwank, Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair, eLife, 2018, 7:e33761

4. Yizhou Li*, Roberto De Luca, Samuele Cazzamalli, Francesca Pretto, Davor Bajic, Jörg Scheuemann*, and Dario Neri*, “Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold” Nature Chemistry, 2018. 10, 441-448.

5. Yizhou Li, Gunther Zimmermann, Jörg Scheuemann, and Dario Neri*, “Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections” ChemBioChem. 2017. 18, 848-852.

   Selected as the issue’s back cover

6. Gunther Zimmermann, Yizhou Li, Jörg Scheuemann, and Dario Neri*, “Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries” ChemBioChem. 2017. 18, 853-857.

7. Yizhou Li, Elena Gabriele, Florent Samain, Nicholas Favalli, Filippo Sladojevich, Jörg Scheuemann, and Dario Neri*, “Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries” ACS Comb. Sci. 2016. 18, 438-443.

8. Xinping Chen, Chunyue Zhao, Xiaolong Li, Tao Wang, Yizhou Li, Cheng Cao, Yuehe Ding, Mengqiu Dong, Lorenzo Finci, Jia-huai Wang,* Xiaoyu Li* and Lei Liu*, Li* and Lei Liu* “Terazosin activated Pgk1 and Hsp90 to promote stress resistance” Nat. Chem. Biol. 2015, 11, 19-25.

9. Peng Zhao, Zitian Chen, Yizhou Li, Dawei Sun, Yuan Gao, Yanyi Huang* and Xiaoyu Li*, “Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets” Angew. Chem. Int. Ed. 2014, 53, 10056-10059.

   Selected as “hot paper” and the issue’s front cover

10. Yizhou Li, Peng Zhao,Mingda Zhang, Xianyuan Zhao, and Xiaoyu Li*, “Multistep DNA-templated synthesis using a universal template” J. Am. Chem. Soc. 2013, 135, 17727−17730.

    Highlighted by “JACS Spotlights”

11. Yizhou Li, Mingda Zhang, Chi Zhang, and Xiaoyu Li*, “Detection of bond formations by DNA-programmed chemical reactions and PCR amplification” Chem. Commun., 2012, 48, 9513-9515.

12. Chi Zhang, Yizhou Li, Mingda Zhang, and Xiaoyu Li*, “DNA-directed formation of peptide bond: a model study towards DNA-programmed peptide ligation” Tetrahedron, 2012, 68, 5152-5156.

13. Yizhou Li, Zheng Zhu and Xiaoyu Li* “Drug Discovery by DNA Programming” in New Frontiers in Chemical Biology: Enabling Drug Discovery, Royal Society of Chemistry Drug Discovery Series, 2010, ISBN-10: 184973125X, pp 257-301.

14. Yizhou Li, Bijie Li, XingYu Lu, Song Lin, and Zhangjie Shi* “Cross Dehydrogenative Arylation (CDA) of a Benzylic CH Bond with Arenes by Iron Catalysis”, Angew. Chem. Intl. Ed. Eng. 2009, 48, 3817-3820.

    Selected as “hot paper”

15. Bijie Li, Yizhou Li, Xingyu Lu, Jia Liu, Bingtao Guan, and Zhangjie Shi* “Cross-Coupling of Aryl/Alkenyl Pivalates with Organozinc Reagents through Nickel-Catalyzed CO Bond Activation under Mild Reaction Conditions” Angew. Chem. Intl. Ed. Eng. 2008, 47, 10124-10127.

16. Shangdong Yang, Changliang Sun, Zhao Fang, Bijie Li, Yizhou Li, and Zhangjie Shi* “Palladium-Catalyzed Direct Arylation of (Hetero)Arenes with Aryl Boronic Acids” Angew. Chem. Intl. Ed. Eng. 2008, 47, 1473-1476.

17. Guixing Cai, Ye Fu, Yizhou Li, Xiaobing Wan, and Zhangjie Shi*, “Indirect ortho Functionalization of Substituted Toluenes through ortho Olefination of N, N-Dimethylbenzylamines Tuned by the Acidity of Reaction Conditions” J. Am. Chem. Soc. 2007, 129, 7666-7673.