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李亦舟 研究员 课题组
2017-10-12 09:13   审核人:


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    李亦舟 研究员

    邮箱:yizhouli@cqu.edu.cn






教育及工作经历

2017.09-至今  重庆大学药学院•创新药物研究中心,重庆大学“百人计划”特聘研究员(博士生导师)

2014.09-2017.08 瑞士苏黎世联邦理工大学(ETH),药学博士后,合作导师:Prof. Dario Neri

主要研究领域:药物发现新技术

2009.09-2014.07 北京大学,有机化学专业,理学博士,导师:李笑宇研究员

主要研究领域:DNA模版控制,分子库合成,靶点识别

2005.09-2009.07北京大学,化学专业,理学学士, 导师:施章杰教授

主要研究领域:通过金属催化的惰性化学键活化

研究领域

设计,化学生物学,有机化学

  1. 以核酸编码化合库(DNA-encoded library)筛选技术为手段的新药先导化合物研究;

  2. 以核酸作为工具的化学生物学研究;

  3. 对生物大分子的选择性化学修饰;

  4. 活性小分子探针设计、合成及靶点识别。

获奖情况

  1. 2016年 第十一届春晖杯创新创业大赛优胜奖 (教育部、科技部科技部)

  2. 2013年 博士生国家奖学金 (教育部)

  3. 2011年 常青奖学金 (北京大学)

  4. 2009年挑战杯一等奖 (北京大学)

主要代表性论文

1.  Yizhou Li, Gunther Zimmermann, Jörg Scheuemann, and Dario Neri*, “Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections” ChemBioChem. 2017. 18, 848-852.

      ·  Selected as the issue’s back cover

2.  Gunther Zimmermann, Yizhou Li, Jörg Scheuemann, and Dario Neri*, “Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries” ChemBioChem. 2017. 18, 853-857.

3.  Yizhou Li, Elena Gabriele, Florent Samain, Nicholas Favalli, Filippo Sladojevich, Jörg Scheuemann, and Dario Neri*, “Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries” ACS Comb. Sci. 2016. 18, 438-443. 

4.  Xinping Chen, Chunyue Zhao, Xiaolong Li, Tao Wang, Yizhou Li, Cheng Cao, Yuehe Ding, Mengqiu Dong, Lorenzo Finci, Jia-huai Wang,* Xiaoyu Li* and Lei Liu*,  Li* and Lei Liu* “Terazosin activated Pgk1 and Hsp90 to promote stress resistance” Nat. Chem. Biol. 2015, 11, 19-25.

5. Peng Zhao, Zitian Chen, Yizhou Li, Dawei Sun, Yuan Gao, Yanyi Huang* and Xiaoyu Li*, “Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets” Angew. Chem. Int. Ed. 2014, 53, 10056-10059.

     ·  Selected as “hot paper” and the issue’s front cover

6.  Yizhou Li, Peng Zhao,Mingda Zhang, Xianyuan Zhao, and Xiaoyu Li*, “Multistep DNA-templated synthesis using a universal template” J. Am. Chem. Soc. 2013, 135, 1772717730.

     ·  Highlighted by “JACS Spotlights”

7.  Yizhou Li, Mingda Zhang, Chi Zhang, and Xiaoyu Li*, “Detection of bond formations by DNA-programmed chemical reactions and PCR amplification” Chem. Commun., 2012, 48, 9513-9515.

8.  Chi Zhang, Yizhou Li, Mingda Zhang, and Xiaoyu Li*, “DNA-directed formation of peptide bond: a model study towards DNA-programmed peptide ligation” Tetrahedron, 2012, 68, 5152-5156.

9.  Yizhou Li, Zheng Zhu and Xiaoyu Li* “Drug Discovery by DNA Programming” in New Frontiers in Chemical Biology: Enabling Drug Discovery, Royal Society of Chemistry Drug Discovery Series, 2010, ISBN-10: 184973125X, pp 257-301.

10.   Yizhou Li, Bijie Li, XingYu Lu, Song Lin, and Zhangjie Shi* “Cross Dehydrogenative Arylation (CDA) of a Benzylic CH Bond with Arenes by Iron Catalysis”, Angew. Chem. Intl. Ed. Eng. 2009, 48, 3817-3820.

      · Selected as “hot paper”

11.  Bijie Li, Yizhou Li, Xingyu Lu, Jia Liu, Bingtao Guan, and Zhangjie Shi* “Cross-Coupling of Aryl/Alkenyl Pivalates with Organozinc Reagents through Nickel-Catalyzed CO Bond Activation under Mild Reaction Conditions” Angew. Chem. Intl. Ed. Eng. 2008, 47, 10124-10127.

12.  Shangdong Yang, Changliang Sun, Zhao Fang, Bijie Li, Yizhou Li, and Zhangjie Shi* “Palladium-Catalyzed Direct Arylation of (Hetero)Arenes with Aryl Boronic Acids” Angew. Chem. Intl. Ed. Eng. 2008, 47, 1473-1476.

13.  Guixing Cai, Ye Fu, Yizhou Li, Xiaobing Wan, and Zhangjie Shi*, “Indirect ortho Functionalization of Substituted Toluenes through ortho Olefination of N, N-Dimethylbenzylamines Tuned by the Acidity of Reaction Conditions” J. Am. Chem. Soc. 2007, 129, 7666-7673. 


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