Recently, Professor Yan Hailong group at the School of Pharmaceutical Science of Chongqing University published a paper entitled “Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N-Aryl Indoles via Vinylidene Ortho-Quinone Methides”.

Atropisomeric heterobiaryl motifs are commonly found in natural products, pharmaceuticals, and bioactive molecules. They are also used as ligands or organocatalysts in asymmetric reactions. Thus, the stereoselective construction of axially chiral heterobiaryl motifs is important in synthetic organic chemistry and other fields. Recently, Professor Hailong Yan's group has developed an atroposelectively diversity-oriented synthetic route for a variety of axially chiral heterobiaryls through organocatalytic asymmetric intramolecular annulation of VQM intermediates with various nucleophilic functionalities.

Reference:

"Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N-Aryl Indoles via Vinylidene Ortho-Quinone Methides" D. Xu, S. Huang, F. Hu, L. Peng, S. Jia, H. Mao, X. Gong, F. Li, W. Qin, H. Yan* CCS Chemistry 2021, 3, 2680-2691.