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张敏职称：教授/博导 学历：博士 邮箱：023-65678472 电话：023-65678472 |
- 个人/团队介绍
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信息整理中...
- 学习工作经历
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2003年7月 毕业于四川大学华西药学院，获得理学学士学位； 2009年7月 毕业于四川大学华西药学院，获得理学博士学位，师从秦勇教授，完成了吲哚生物碱Minfiensine和Vincorine的全合成； 2009年9月~2013年8月 美国威斯康辛大学麦迪逊分校博士后研究，师从Weiping Tang教授，从事Harringtonolide，Fortunolide A and Welwitindolinones等复杂天然产物的全合成研究； 2013年8月~至今 重庆大学创新药物研究中心，特聘研究员，博士生导师。
- 研究领域
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(1) 具有重要生理活性的复杂天然产物的全合成及构效关系研究
(2) 新型有机反应方法学的发展及其在活性化合物合成中的应用
- 项目成果
- 代表性文章
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1. Zhang, M.; Liu, N. and Tang, W. Stereoselective Total Synthesis of Hainanolidol and Harringtonolide via Oxidopyrylium-Based [5+2] Cycloaddition. J. Am. Chem. Soc., 2013, 135, 12434.
2. Liu, R.; Zhang, M.; Winston-McPherson, G. and Tang, W. Ring Expansion of Alkynyl Cyclopropanes to Highly Substituted Cyclobutenes via a N-Sulfonyl-1,2,3- Triazole Intermediate. Chem. Commun., 2013, 49, 4376.
3. Zhang, M. and Tang, W. Synthesis of Functionalized Cyclohexenone Core of Welwitindolinones via Rhodium-Catalyzed [5 + 1] Cycloaddition. Org. Lett., 2012, 14, 3756.
4. Shu, D.; Li, X.; Zhang, M.; Robichaux, P. J.; Guzei, I. A. and Tang, W. Rhodium-Catalyzed Carbonylation of Cyclopropyl Substituted Propargyl Esters: A Tandem 1,3-Acyloxy Migration [5 + 1] Cycloaddition. J. Org. Chem., 2012, 77, 6463.
5. Liu, R.; Zhang, M. ; Wyche, T. P.; Winston-McPherson, G. N.; Bugni, T. S. and Tang, W. Stereoselective Preparation of Cyclobutanes with Four Different Substituents: Total Synthesis and Structural Revision of Pipercyclobutanamide A and Piperchabamide G. Angew. Chem. Int. Ed., 2012, 51, 7503.
6. Zhang, D.; Zhang, M. ; Ding, B.; Wang, X. –L.; Qiu, Z. –Y.and Qin, Y. Synthesis of a novel phosphate analog of 20-hydroxyecdysone with potent hypoglycemic activity, J. Asian. Nat. Prod. Res., 2011, 13(4), 297.
7. Li, X.; Zhang, M. ; Shu, D.; Robichaux, P. J.; Huang, S. and Tang, W. Rhodium-catalyzed Ring Expansion of Cyclopropanes to Seven-membered Rings via 1,5-C-C Bond Migration. Angew. Chem. Int. Ed., 2011, 50 , 10421.
8. Shu, D.; Li, X.; Zhang, M. ; Robichaux, P. J. and Tang, W. Synthesis of Highly Functionalized Cyclohexenone Rings: Rhodium-Catalyzed 1,3-Acyloxy Migration and Subsequent [5+1] Cycloaddition. Angew. Chem. Int. Ed., 2011, 50, 1346.
9. Zhang, M. ; Huang, X.; Shen, L. and Qin, Y. Total Synthesis of the Akuammiline Alkaloid (±)-Vincorine. J. Am. Chem. Soc., 2009, 131, 6013.
10. Shen, L.; Zhang, M. (co-first author) ; Wu, Y. and Qin, Y. Efficient Assembly of a...
