2013.7至今：重庆大学药学院，讲师、副教授；

2012.8-2013.4：北京保诺科技有限公司，高级研究员；

2007.9-2012.7：北京大学药学院，博士；

2000.9-2007.7：陕西师范大学化学化工学院，学士，硕士。

基于“特洛伊木马”策略的抗生素开发；

基于“糖”的药物开发；

基于结构的药物设计与筛选。

1. 重庆市面上项目（靶向肺炎链球菌的铁载体-甲氨蝶呤偶联 物的设计、合成及抗菌活性研究，编号：CSTB2023NSCQ-MSX0949，主持）

2. 中央高校前沿交叉项目（新型“特洛伊木马”抗菌偶联物的合成及活性研究，项目编号：2021CDJQY-020，主持）

3. 重庆市面上项目（Galectin-3蛋白靶向降解嵌合分子的设计、合成及抗肿瘤活性研究项目，编号：cstc2019jcyj-msxmX0057，主持）

4. 国家自然基金应急项目（海洋天然产物neristatin 1的全合成及抗肿瘤构效关系研究，项目编号：817411692018.3，主持）

5. 企业横向（抗菌前药/抗菌纳米前药的设计、合成及抗菌活性研究，参与）

(1) Zhou, P.; Du, Y.; Ran, K.; Pan, Z.; Liu, M.; Deng, H.; He, Y.*; Zhang, S.-L.*; Guo, J.* Modular Synthesis of Desferrioxamine B and Its Methotrexate Conjugate as a Selective Trojan Horse Antibiotic That Targets Streptococcus pneumoniae. Org. Lett. 2025, 27, 1719–1723.

(2) Li, T.; Zhang, R.; Gong, H.; Tang, Z.; Li, X.; Gong, Z.; Challa, M.; Zou, C.; Zhang, S.-L.*; Guo, J.*; He, Y.* Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections. Eur. J. Med. Chem. 2025, 289, 117483.

(3) Li, T.; Tang, Z.; Zhang, R.; Challa, M.; Gong, H.; Gong, Z.; Zhang, S.-L.*; Guo, J.*; He, Y.* Targeted Vancomycin Delivery via in situ Albumin Conjugation and Acid-triggered Drug Release for Reduced Nephrotoxicity. Eur. J. Med. Chem. 2025, 117652.

(4) Yang, X.; Shi, G.; Lin, Z.; Qiu, Y.; Liu, F.; Hu, K.; Guo, J.*; Peng, H.*; He, Y.* Pathogen-targeting Biomineralized Bacterial Outer Membrane Vesicles for Eradicating Both Intracellular and Extracellular Staphylococcus aureus. J. Control. Rel. 2025, 382, 113702.

(5) Zhao, S.; Wang, Z.-P.; Lin, Z.; Wei, G.; Wen, X.; Li, S.; Yang, X.; Zhang, Q.; Jing, C.; Dai, Y.; Guo, J.*; He, Y.* Drug Repurposing by Siderophore Conjugation: Synthesis and Biological Evaluation of Siderophore-Methotrexate Conjugates as Antibiotics. Angew. Chem. Int. Ed. 2022, 61, e202204139.

(6) Zhao, S.; Wang, Z.-P.; Wen, X.; Li, S.; Wei, G.; Guo, J.*; He, Y.* Synthesis of Vitamin B12-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria. Org. Lett. 2020, 22, 6632–6636. 

(7) Lagishetti, C.; Banne, S.; You, H.; Tang, M.; Guo, J.*; Qi, N.*; He, Y.* Construction of Bridged-Ring-Fused Naphthalenone Derivatives Through an Unexpected Zn(OTf)2-Catalyzed Cascade Transformation. Org. Lett. 2019, 21, 5301–5304.

(8) Liu, Y.; Wang, Z.-P.; Banne, S.; Guo, J.*; He, Y. * Toward the Total Synthesis of Scabrosins: Synthesis of a Desulfur-scabrosin Skeleton and Its Stereoisomers. J. Org. Chem. 2019, 84, 5838–5845.

(9) Lin, Z.; Xu, X.; Zhao, S.; Yang, X.; Guo, J.; Zhang, Q.; Jing, C.; Chen, S.; He, Yun, Total Synthesis, and Antimicrobial Evaluation of Natural Albomycins against Clinical Pathogens. Nat. Commun. 2018, 9, 3445.

(10) Banne, S.; Reddy, D. P.; Li, W.; Wang, C.; Guo, J.*; He, Y.* A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G. Org. Lett. 2017, 19, 4996–4999.