李杨峰

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李杨峰

Title:副研究员/硕导

E-mail Address:yfli3@cqu.edu.cn

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个人/团队介绍

药物化学生物学团队课题组网站:https://www.x-mol.com/groups/li_yizhou

学习工作经历

2022.09-至今        重庆大学药学院,副研究员

2020.09-2022.08  重庆大学药学院准聘副教授

2017.09-2020.08  美国伊利诺伊大学芝加哥分校,药物化学博士后(导师 Prof. Gregory Thatcher

2012.09-2017.07  中国科学院上海有机化学研究所,药物化学,博士(导师:王任小 研究员)

2008.09-2012.07  中国药科大学,基础药学理科基地班,学士(导师:陆涛 教授)

研究领域

药物化学生物学药物设计


1. 针对表观遗传中溴结构域蛋白设计合成选择性抑制剂用于癌症、炎症等疾病的研究。

2. 针对细胞自吞噬过程中重要蛋白的化学小分子探针开发。

3. 开发DNA兼容的化学反应并用于DNA编码化合物库(DNA-encoded library)的构建。

项目成果

1. 国家自然科学基金青年基金,主持2022.01-2024.12

2. 重庆市留学人员回国创业创新支持计划项目主持2023.07-2025.06



代表性文章

1. Yangfeng Li#, Zhengnan Shen#Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory Thatcher*, Rui Xiong*; Structure-Guided Design and Synthesis of Pyridinone-Based Selective BET-BD1 inhibitors, J. Med. Chem. 2024, 67, 2712-2731.

2. Yangfeng Li, Jiong Zhao, Lauren Gutgesell, Zhengnan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Huiping Zhao, Fei Huang, Debra Tonetti, Gregory Thatcher*, Rui Xiong*; Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib; J. Med. Chem. 2020, 63, 7186-7210.

3. Laura Cooper#, Adam Schafer#, Yangfeng Li#,(共同一作) Han Cheng, Bani Medegan Fagla, Zhengnan Shen, Raghad Nowar, Katherine Dye, Manu Anantpadma, Robert Davey, Gregory Thatcher, Lijun Rong*, Rui Xiong*; Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors; J. Med. Chem2020, 63, 11085-11099.

4. Shilian Yang#, Guixian Zhao#, Yuting Gao, Yang Sun, Xiaohong Fan, Gong Zhang, Yangfeng Li*, Yizhou Li*; In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries, Chem. Sci. 2022,13, 2604-2613.

5. Xianfu Fang#, Yiting Wang#, Pengyang He, Huilin Liao, Gong Zhang, Yangfeng Li*, Yizhou Li*; Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries, Org. Lett. 202224, 3291-3296.

6. Yangfeng Li, Biao Yu, Renxiao Wang*; Efficient Synthesis of Rottlerin and Its Two Subunits, Tetrahedron Lett. 2016, 57, 1856-1859.

7. Yangfeng Li, Biao Yu, Jiansong Song*, Renxiao Wang*; Efficient Synthesis of Baicalin and Its analogs, Tetrahedron Lett. 2015, 56, 3816-3819.