李杨峰Title:副研究员/硕导 E-mail Address:yfli3@cqu.edu.cn Tel.: |
药物化学生物学团队课题组网站:https://www.x-mol.com/groups/li_yizhou
2022.09-至今 重庆大学药学院,副研究员
2020.09-2022.08 重庆大学药学院,准聘副教授
2017.09-2020.08 美国伊利诺伊大学芝加哥分校,药物化学,博士后(导师: Prof. Gregory Thatcher)
2012.09-2017.07 中国科学院上海有机化学研究所,药物化学,博士(导师:王任小 研究员)
2008.09-2012.07 中国药科大学,基础药学理科基地班,学士(导师:陆涛 教授)
药物化学生物学,药物设计
1. 针对表观遗传中溴结构域蛋白设计合成选择性抑制剂用于癌症、炎症等疾病的研究。
2. 针对细胞自吞噬过程中重要蛋白的化学小分子探针开发。
3. 开发DNA兼容的化学反应并用于DNA编码化合物库(DNA-encoded library)的构建。
1. 国家自然科学基金青年基金,主持,2022.01-2024.12
2. 重庆市留学人员回国创业创新支持计划项目,主持,2023.07-2025.06
1. Yangfeng Li#, Zhengnan Shen#, Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory Thatcher*, Rui Xiong*; Structure-Guided Design and Synthesis of Pyridinone-Based Selective BET-BD1 inhibitors, J. Med. Chem. 2024, 67, 2712-2731.
2. Yangfeng Li, Jiong Zhao, Lauren Gutgesell, Zhengnan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Huiping Zhao, Fei Huang, Debra Tonetti, Gregory Thatcher*, Rui Xiong*; Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib; J. Med. Chem. 2020, 63, 7186-7210.
3. Laura Cooper#, Adam Schafer#, Yangfeng Li#,(共同一作) Han Cheng, Bani Medegan Fagla, Zhengnan Shen, Raghad Nowar, Katherine Dye, Manu Anantpadma, Robert Davey, Gregory Thatcher, Lijun Rong*, Rui Xiong*; Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors; J. Med. Chem. 2020, 63, 11085-11099.
4. Shilian Yang#, Guixian Zhao#, Yuting Gao, Yang Sun, Xiaohong Fan, Gong Zhang, Yangfeng Li*, Yizhou Li*; In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries, Chem. Sci. 2022,13, 2604-2613.
5. Xianfu Fang#, Yiting Wang#, Pengyang He, Huilin Liao, Gong Zhang, Yangfeng Li*, Yizhou Li*; Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries, Org. Lett. 2022, 24, 3291-3296.
6. Yangfeng Li, Biao Yu, Renxiao Wang*; Efficient Synthesis of Rottlerin and Its Two Subunits, Tetrahedron Lett. 2016, 57, 1856-1859.
7. Yangfeng Li, Biao Yu, Jiansong Song*, Renxiao Wang*; Efficient Synthesis of Baicalin and Its analogs, Tetrahedron Lett. 2015, 56, 3816-3819.