王震

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王震

Title:副教授

E-mail Address:wangz1114@cqu.edu.cn

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个人/团队介绍
学习工作经历

201511月-至今:重庆大学药学院(创新药物研究中心),专任教师/副教授;

20148月-201511月:新加坡国立大学,博士后,导师:Prof. Lu Yixin

20099月-20147月:四川大学化学学院,理学博士,导师:冯小明院士;

20059月-20096月:四川大学化学学院,理学学士,导师:冯小明院士。


研究领域

不对称合成方法学(有机催化/手性路易斯酸催化)

药物化学,生物活性化合物的合成研究

不对称催化是化学学科以及药物化学领域的前沿和研究热点,是获得光学活性化合物最高效的途径。王震博士长期从事有机合成和不对称催化工作,在手性金属配合物催化(主要是镧系路易斯酸金属催化,博士期间)以及有机小分子催化(手性氨基酸衍生的有机膦催化,博士后期间)等方面进行了系统的研究,取得了系列开拓性的创新成果。王震博士已在J. Am. Chem. Soc.Angew.Chem. Int. Ed.Chem. Commun.Org. Lett.等国际权威刊物上发表论文多篇。

项目成果
代表性文章

一、编写书籍、章节

(2) Xiaoming Feng*, Zhen Wang, Xiaohua Liu, Chiral Lewis Acid, “Chiral Lewis Acid Rare-Earth Metal Complexes in Enantioselective Catalysis”, Springer International Publishing AG, 2017, 147-192, DOI: 10.1007/3418_2017_1.

 

(1) Xiaoming Feng, Zhen Wang, Lili Lin, Electronic Encyclopedia of Reagents for Organic Synthesis, “1,3-Dicyclohexylcarbodiimide”, Wiley, 2017, 5-9.

 

二、论文发表

(25) Zhen Wang, Xiaohua Liu*, Xiaoming Feng*, “Asymmetric Catalysis Enabled by Chiral N,N'-Dioxide–Nickel(II) Complexes”, Aldrichimica Acta 202053, 3.

 

(24) Xin Wang, Mengxue Lu, Qin Su, Minghui Zhou, Yesu Addepalli, Weijun Yao, Zhen Wang* and Yixin Lu*,“Phosphine-catalyzed [4+2] cycloadditions of allenic ketones: Enantioselective synthesis of functionalized tetrahydropyridines”, Chem. Asian J. 201914, 3409-3413.

 

(23) Zhen Wang*, Yesu Addepalli, and Yun He*, “Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes”, Org. Lett. 201820, 644.

 

(22) Yesu Addepalli, Xiaohong Yang, Minghui Zhou, D. Prabhakar Reddy, Shao-Lin Zhang, Zhen Wang* and Yun He*, “Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines”, Eur. J. Med. Chem. 2018151, 214.

 

(21) Minghui Zhou, Qin Su, Yesu Addepalli, Yun He* and Zhen Wang*, “An asymmetric Mannich reaction of α-diazocarbonyl compounds and N-sulfonyl cyclic ketimines catalyzed by complexes generated from chiral and achiral phosphines with gold(I)”, Org. Biomol. Chem. 201816, 2923.

 

(20) Yesu Addepalli, Zhimei Yu, Jie Ji, Cheng Zou, Zhen Wang* and Yun He*, “Tandem Diels–Alder/oxidation–aromatization reactions involving 2-styrylchromones and arynes”, Org. Biomol. Chem. 201816, 6077.

 

(19) Prabhakar Reddy, Ning Zhang, Zhimei Yu, Zhen Wang, Yun He*, “Total Synthesis of Kanamienamide”. J. Org. Chem., 201782, 11262.

(18) Zhen Wang,* Tianli Wang, Weijun Yao and Yixin Lu* “Phosphine-Catalyzed Enantioselective [4 + 2] Annulation of o-Quinone Methides with Allene Ketones”, Org. Lett. 201719, 4126.

 

(17) Zhen Wang*, Huacheng Xu, Qin Su, Ping Hu, Pan-Lin Shao, Yun He and Yixin Lu* “Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4+2]/[2+2] Cyclizations”, Org. Lett. 201719, 3111.

 

(16) I. N. Chaithanya Kiran,† R. Santhosh Reddy,† Chandraiah Lagishetti, Huacheng Xu, Zhen Wang*, Yun He* “Selective Aza Diels-Alder and Domino [4+2]/[2+2] Cycloaddition Reactions of Arynes with N-Sulfonyl Ketimines”, J. Org. Chem. 201782, 1823.

 

(15) Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili. Lin and Xiaoming Feng*, "Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N’-Dioxide–Metal Complexes" Angew. Chem. Int. Ed. 2012, 51, 2776.

 

(14) Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N’-Dioxide Complexes: Metal-Directed Switch in Enantioselectivity”, Angew. Chem. Int. Ed.201150, 4928.

 

(13) Zhen Wang, Tengfei Kang, Qian Yao, Jie Ji, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Scandium-Catalyzed Asymmetric 1,6-Addition of 3-Substituted Oxindoles to Linear Dienyl Ketones" Chem. Eur. J. 2015, 21, 7709.

 

(12) Zhen Wang, Zuliang Zhang, Qian Yao, Xiaohua Liu, Yunfei Cai, Lili Lin and Xiaoming Feng*, "Highly Stereoselective Conjugate Addition and α-Alkynylation Reaction with Electron-Deficient Alkynes Catalyzed by Chiral Scandium(III) Complexes" Chem. Eur. J. 2013, 19, 8591.

 

(11) Zhen Wang, Qian Yao, Tengfei Kang, Juhua Feng, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Highly Diastereo- and Enantioselective Michael Addition of 3-Substituted Benzofuran-2(3H)-ones to 4-Oxo-enoates Catalyzed by Lanthanide(III) Complexes" Chem. Comm.2014,50, 4918.

 

(10) Zhen Wang, Donghui Chen, Zhigang Yang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Synthesis of α-Stereogenic Esters through Catalytic Asymmetric Michael Addition of 4-Oxo-4-arylbutenoates" Chem. Eur. J. 201016, 10130.

 

(9) Tengfei Kang, Zhen Wang, Lili Lin, Yuting Liao, Yuhang Zhou, Xiaohua Liu, and Xiaoming Feng* “N,N’-Dioxide/Zinc Bis(trifluoromethylsulfonyl)imide Complex Catalyzed Enantioselective Diels–Alder Reaction of Cyclopentadiene with Alkynones”, Adv. Synth. Catal. 2015357, 2045.

 

(8) Qian Yao, Zhen Wang, Yuheng Zhang, Xiaohua Liu, Lili Li, and Xiaoming Feng*, “N,N’-Dioxide/Gadolinium(III)-Catalyzed Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Pyrazolamides”, J. Org. Chem.201580, 5704.

 

(7) Sha Bai, Xiaohua Liu, Zhen Wang, Weidi Cao, Lili Lin and Xiaoming Feng*. "Catalytic Asymmetric Friedel–Crafts Reaction of Activated Phenols and 4-Oxo-4-arylbutenoates" Adv. Synth. Catal. 2012354, 2096–2100.

 

(6) Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,N’-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives" Org. Lett.201113, 596-599.

 

(5) Donghui Chen, Zhen Wang, Jiangting Li, Zhigang Yang, Lili Lin, Xiaohua Liu and Xiaoming Feng*. "Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates: Highly Enantioselective Synthesis of Multisubstituted Isoxazolidines" Chem. Eur. J. 2011, 17, 5226 – 5229.

 

(4) Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex" Chem. Eur. J. 201016, 6632 – 6637.

 

(3) Jie Liu, Zhigang Yang, Xiaohua Liu, Zhen Wang, Yanling Liu, Sha Bai, Lili Lin and Xiaoming Feng*. "Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine" Org. Biomol. Chem., 20097, 4120–4127.

 

(2) Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins" Adv. Synth. Catal. 2008, 350, 2001 – 2006.

 

(1) Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine" J. Am. Chem. Soc. 2008130, 5654–5655.