夏熠

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夏熠

Title:副教授

E-mail Address:yixia@cqu.edu.cn

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个人/团队介绍
学习工作经历

20149月-至今 重庆大学药学院,副教授

20129月-20148 加拿大英属哥伦比亚大学,温哥华前列腺研究中心,博士后

20111月-20128 法国马赛纳米跨学科研究中心,助理研究员

20081月-201012 法国马赛纳米跨学科研究中心,博士后

20079月-200711 法国地中海大学化学系,访问学者

20076 武汉大学,生物有机化学理学博士

20026 武汉大学,化学理学学士


研究领域

核苷/核酸类药物的合成与活性评估,药物抗肿瘤机制研究,超分子自组装纳米药物载体

项目成果
代表性文章

1.Zhengwei Zhou#, Biyao Luo#, Xi Liu #, Mimi Chen, Wenjun Lan, Juan L. Iovanna, Ling Peng*, Yi Xia*. Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation. Chem. Commun., 2019, 55, 8919-8922. (Inside cover)

2.Patricia Santofimia-Castaño#Yi Xia#, Wenjun Lan#, Zhengwei Zhou, Can Huang, Ling Peng, Philippe Soubeyran, Adrián Velázquez-Campoy, Olga Abián, Bruno Rizzuti, José L. Neira*, Juan Iovanna*. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J. Clin. Invest. 2019, 129, 2500-2513. (# co-first author

3.Patricia SantofimiaCastaño, Bruno Rizzuti, Yi Xia, Olga Abian, Ling Peng, Adrián VelázquezCampoy, José L. Neira*, Juan Iovanna*. Targeting intrinsically disordered proteins involved in cancer. Cell. Mol. Life Sci. 2019, doi: 10.1007/s00018-019-03347-3.

4.Zhengwei Zhou#, Mei Cong#, Mengyao Li, Aura Tintaru, Jia Li, Jianhua Yao, Yi Xia*, Ling Peng*. Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates. Chem. Commun.201854, 5956-5959. (Inside cover)

5.Mimi Chen, Zhengwei Zhou, Yaxiong Suo, Mengyao Li, Jianhua Yao, Ling Peng, Yi Xia*. Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation. New J. Chem.201741, 8509-8519.

6.Yi Xia*, Menghua Wang, Eliana Beraldi, Mei Cong, Amina Zoubeidi, Martin Gleave, Ling Peng*. A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor, Anticancer Agents Med. Chem. 2015, 15, 1333-1340.

7.Yi Xia, Ling Peng*. Photoactivatable Lipid Probes for Studying Biomembranes by Photoaffinity Labeling. Chem. Rev. 2013113, 7880-7929. (Cover paper)

8.Yi Xia, Menghua Wang, Olivier Demaria, Jingjie Tang, Palma Rocchi, Fanqi Qu, Juan L. Iovanna, Lena Alexopoulou, Ling Peng*. A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity. J. Med. Chem. 201255, 5642-6646.