Hui Chen

The Chen Research Group focuses on developing new methods and strategies to deliver functional genes or proteins for the treatment of various human illnesses such as cancer, infectious diseases, and metabolic diseases.

2018.11-Present：Lecturer, School of Pharmacy, Innovative Drug Research Centre, Chongqing University, Chongqing, China

2017.1-2018.3：Postdoctoral Fellow, University of Illinois at Chicago, USA

2011.9-2016.7：Ph.D., Institute of Chemistry Chinese Academy of Sciences, Beijing, China

2007.9-2011.7：B.S., College of Sciene, China Agricultural University, Beijing, China

Chemical biology, Nanomaterials, Targeted drugs

Awards and Honors

the third prize of "Outstanding Papers of the Sencond Sichuan-Chongqing Science and Technology Academic Conference" (2021).

Grants and fundings

Grants:

1. Oligofluorene compounds and their preparation methods. (ZL 201510193886.0.)

2. Oligofluorene and its preparation method. (ZL 201510192530.5)

Fundings:

1. The Startup Funding of Chongqing University (0247001104413)

2. Key projects of Chongqing Natural Science Foundation (02470024320007)

3. Fundamental Research Funds for the Central Universities (2019CDYGYB006)

1.  Lan Yang, Xiao He, Zhiying Zeng, Jiakun Tang, Dongmei Qi, Huijie Ma, Hui Chen*, Xinghai Ning* and Xuli Feng*. Clickable amino acid tuned self-assembly of a nucleus-selective multi-component nanoplatform for synergistic cancer therapy. Chem. Sci. 2021, 12, 8394-8400.

2.  Jiakun Tang, Ye Liu, Dongmei Qi, Lan Yang, Hui Chen*, Chenhui Wang*, Xuli Feng*. Nucleus-Targeted Delivery of Multi-Protein Self-Assembly for Combined Anticancer Therapy. Small 2021, 17, 2101219.

3.  Zhiying Zeng, Xiao He, Changying Li, Shan Lin, Hui Chen*, Libing Liu*, Xuli Feng*. Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease. Biomaterials 2021, 271, 120753.

4.  Xiao He, Lan Yang, Hang Su, Shan Lin, Dongmei Qi, Hui Chen*, Yunfeng Qu*, Libing Liu*, Xuli Feng*. Clickable amino acid derivative tuned self-assembly of antigen and adjuvant for effective immunotherapy. J. Control. Release 2021, 337, 306-316.

5.  Hui Chen, Meng Li, Zhang Liu, Rong Hu, Shengliang Li, Fengting Lv*, Libing Liu, Yilin Wang, and Shu Wang*.Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability. Sci. China-Chem. 2018, 61, 113-117.

6.  Hui Chen, Bing Wang, Jiangyan Zhang, Chenyao Nie, Fengting Lv*, Libing Liu, and Shu Wang*. Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with embrane-disrupting ability. Chem. Commun. 2015, 51, 4036-4039.

7.  Haotian Bai, Hui Chen, Rong Hu, Meng Li, Fengting Lv*, Libing Liu, and Shu Wang*. Supramolecular conjugated polymer naterials for in situ pathogen detection. ACS Appl. Mater. Interfaces, 2016, 8, 31550-31557.

8.  Yaokun Wang, Hui Chen, Meng Li, Rong Hu, Fengting Lv *, Libing Liu*, Shu Wang*. Synthesis of a new cationic non-conjugated polymer for discrimination of microbial pathogens. Polym. Chem. 2016, 7, 6699-6702.

9.  Pengbo Zhang, Shengliang Li, Hui Chen, Xiaoyu Wang, Libing Liu*, Fengting Lv, Shu Wang*. Biofilm inhibition and elimination regulated by cationic conjugated polymers. ACS Appl. Mater. Interfaces 2017, 9, 16933-16938.

10.  Jianwu Wang, Shengliang Li, Hui Chen, Rong Hu, Meng Li, Fengting Lv, Libing Liu, Yuguo Ma*, Shu Wang*. An intracellular anchor regulates the distribution of bioactive molecules. Chem. Commun. 2016, 52, 11004-11007.

11.  Chengcheng Zhou, Fengyan Wang, Hui Chen, Meng Li, Fulin Qiao, Zhang Liu, Yanbo Hou, Chunxian Wu, Yaxun Fan, Libing Liu, Shu Wang*, Yilin Wang*. Selective antimicrobial activities and action mechanism of micelles self-assembled by cationic oligomeric surfactant. ACS Appl. Mater. Interfaces 2016, 8, 4242-4249.

12.  Meng Li, Shengliang Li, Hui Chen, Rong Hu, Libing Liu*, Fengting Lv, Shu Wang*, Preparation of Conjugated Polymer Grafted with H₂O₂-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing. ACS Appl. Mater. Interfaces 2016, 8, 42-46.

13.  Shengliang Li, Huanxiang Yuan, Hui Chen, Xiaoyu Wang, Pengbo Zhang, Fengting Lv, Libing Liu, and Shu Wang*. Cationic poly(p-phenylene vinylene) materials as a multifunctional platform for light-enhanced siRNA delivery. Chem. Asian J. 2016, 11, 2686-2689.

14.  Pengbo Zhang, Huan Lu, Hui Chen, Jiangyan Zhang, Libing Liu*, Fengting Lv, Shu Wang*. Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells. Anal. Chem. 2016, 88, 2985-2988.