Yuanwei Dai

2020/11-Present, Chongqing University, School of Pharmaceutical Sciences

2019/04-2020/09, University of Maryland--College Park (UMD), Department of Chemistry and Biochemistry, Postdoctoral Research Fellow. (Supervisor: Prof. Lai-Xi Wang)

2017/04-2019/04, State University of New York at Albany, Department of Chemistry, Postdoctoral Research Fellow. (Supervisor: Prof. Qiang Zhang)

2015/10-2017/04, University of Texas Southwestern Medical Center (UTSW), Department of Biochemistry, Postdoctoral Research Fellow. (Supervisor: Prof. Chuo Chen)

2010/09-2015/07, Ph.D., Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, majored in Organic Chemistry, (Supervisor: Prof. Biao Yu)

2006/09-2010/07, B.S., China Pharmaceutical University, majored in Pharmacy (Basic Class), (Supervisor: Prof. Tao Lu)

Chemical Biology, Glycochemistry, Medicinal Chemistry

1.  Merging synthetic chemistry with glycobiology to explore the relevance of protein glycosylation in cancer and infectious diseases.

2.  Development of novel methodologies for assembling bioactive oligosaccharides and glycoconjugates.

3.  Development of novel small molecular probes for human disease with future theranostic applications.

Grants and fundings

1.  National Natural Science Foundation of China (Youth Program, 22101036)

2.  Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0093)

3.  Venture & Innovation Support Program for Chongqing Overseas Returnees (cx2021051)

1. Dai, Y.; Hartke, R.; Li, C.; Yang, Q.; Liu, J.; Wang, L.-X.* Fluorinated L-Fucose Analogs Inhibit Proliferation of Cancer Cells and Primary Endothelial Cells. ACS Chem. Biol. 2020, 15, 2662–2672.

2. Dai, Y.; Tian, B.; Chen, H.; Zhang, Q.* Palladium-Catalyzed Stereospecific C-Glycosylation of Glycals with Vinylogous Acceptors. ACS Catalysis 2019, 9, 2909–2915. (Selected as Editor’s Choice)

3. Dai, Y.; Weng, J.; George, J.; Chen, H.; Lin, Q.; Wang, J.; Royzen, M.; Zhang, Q.* Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives. Org. Lett. 2019, 21, 3828-3833.

4. Dai, Y.; Zheng, J.; Zhang, Q. * A General Strategy for Stereoselective Synthesis of β-N-Glycosyl Sulfonamides via Palladium-Catalyzed Glycosylation. Org. Lett. 2018, 20, 3923-3927.

5. Dai, Y.; Yu, B.* Total synthesis of astrosterioside A, an anti-inflammatory asterosaponin. Chem. Commun. 2015, 51, 13826-13829.

6. Yang, J.; Dai, Y.; Bartlett, R.; Zhang, Q.* Convergent Palladium-Catalyzed Stereospecific Arginine Glycosylation Using Glycals. Org. Lett. 2021, 23, 4008-4012.

7. Ou, C.; Li, C.; Zhang, R.; Yang, Q.; Zong, G.; Dai, Y.; Francis, R. L.; Bournazos, S.; Ravetch, J. V.; Wang, L.-X.* One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjugate Chem. 2021, 32, 1888–1897.

8. Li, J.; Dai, Y.; Li, W.; Stéphane, L.; Xu, P.; Yu, B.* Effective Synthesis of α-D-GlcN-(1→4)-D-GlcA/L-IdoA Glycosidic Linkage under Gold(I) Catalysis. Asian J. Org. Chem. 2015, 4, 756-762.

9. Xu, P.; Xu, W.; Dai, Y.; Yang, Y.; Yu, B.* Efficient synthesis of a library of heparin tri- and tetrasaccharides relevant to the substrate of heparanase. Org. Chem. Front. 2014, 1, 405-414.