Jian Guo

2016/07-Present, Chongqing University, School of Pharmaceutical Sciences

2013/05-2016/06, Chongqing University, Innovative Drug Research Center.

2012/09-2013/04, BioDuro, Advanced scientist

2007/09-2012/07, Peking University, School of Pharmaceutical Science, PhD.

2004/09-2007/07, Shaanxi Normal University, majored in Organic Chemistry, M.S.

2000/09-2004/07, Shaanxi Normal University, majored in  Chemistry, B.S.

Chemical Biology, Medicinal Chemistry

1. Design, synthesis and evaluation of novel antibiotics

2. Development of carbohydrate-based drugs

Grants and fundings

National Natural Science Foundation of China (81741169)

Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0057)

The Fundamental Research Funds for the Central Universities (2021CDJQY-020)

(1)  Zhao, S.; Wang, Z.-P.; Wen, X.; Li, S.; Wei, G.; Guo, J.*; He, Y.*  Synthesis of  Vitamin B₁₂-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative  Bacteria. Org. Lett. 2020, 22, 6632–6636.

(2)  Lagishetti, C.; Banne, S.; You, H.; Tang, M.; Guo, J.*; Qi, N.*; He, Y.* Construction of Bridged-Ring-Fused Naphthalenone Derivatives Through an Unexpected Zn(OTf)₂-Catalyzed Cascade Transformation. Org. Lett. 2019, 21, 5301–5304.

(3)  Liu, Y.; Wang, Z.-P.; Banne, S.; Guo, J.*; He, Y. * Toward the Total Synthesis of Scabrosins: Synthesis of a Desulfur-scabrosin Skeleton and Its Stereoisomers. J. Org. Chem. 2019, 84, 5838–5845.

(4)  Lin, Z.; Xu, X.; Zhao, S.; Yang, X.; Guo, J.; Zhang, Q.; Jing, C.; Chen, S.; He, Yun, Total Synthesis, and Antimicrobial Evaluation of Natural Albomycins against Clinical Pathogens. Nat. Commun. 2018, 9, 3445.

(5)  Banne, S.; Reddy, D. P.; Li, W.; Wang, C.; Guo, J.*; He, Y.* A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G. Org. Lett. 2017, 19, 4996–4999.

(6)  Guo, J.; Li, W.; Xue, W.; Ye, X.-S.* Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide. J. Med. Chem. 2017, 60, 2135–2141.