Yangfeng Li

Group website of Yizhou Li Group:

https://www.x-mol.com/groups/li_yizhou

2020/09-Present,  Chongqing University, School of Pharmaceutical Sciences

2017/09-2020/08, University of Illinois at Chicago (UIC), majored in Medicinal Chemistry, Postdoctoral Research Associate. (Supervisor: Prof. Gregory R. J. Thatcher)

2012/09-2017/07, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, majored in Organic Chemistry, PhD. (Supervisor: Prof. Renxiao Wang)

2008/09-2012/07, China Pharmaceutical University, majored in Pharmacy (Basic Class), B.S. (Supervisor: Prof. Tao Lu)

Chemical Biology, Medicinal Chemistry

1. Design, synthesis and evaluation of epigenetic proteins (such as BRD4, CBP/p300) inhibitors and their application in cancer and inflammation treatment

2. Development of DNA-compatible reactions for the construction of DNA-encoded library (DEL)

National Natural Science Foundation of China (Youth Program, 22107017)

The Fundamental Research Funds for the Central Universities (2021CDJYGRH-002)

1. Yangfeng Li#, Zhengnan Shen#, Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory Thatcher*, Rui Xiong*; Structure-Guided Design and Synthesis of Pyridinone-Based Selective BET-BD1 inhibitors, J. Med. Chem. 2024, Accepted.

2. Yangfeng Li, Jiong Zhao, Lauren Gutgesell, Zhengnan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Huiping Zhao, Fei Huang, Debra Tonetti, Gregory Thatcher*, Rui Xiong*; Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib; J. Med. Chem. 2020, 63, 7186-7210.

3. Laura Cooper^#, Adam Schafer^#, Yangfeng Li^#, Han Cheng, Bani Medegan Fagla, Zhengnan Shen, Raghad Nowar, Katherine Dye, Manu Anantpadma, Robert Davey, Gregory Thatcher, Lijun Rong*, Rui Xiong*; Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors; J. Med. Chem. 2020, 63, 11085-11099.

4. Shilian Yang^#, Guixian Zhao^#, Yuting Gao, Yang Sun, Xiaohong Fan, Gong Zhang, Yangfeng Li*, Yizhou Li*; In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries, Chem. Sci. 2022,13, 2604-2613.

5. Xianfu Fang^#, Yiting Wang^#, Pengyang He, Huilin Liao, Gong Zhang, Yangfeng Li*, Yizhou Li*; Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries, Org. Lett. 2022, 24, 3291-3296.

6. Yangfeng Li, Biao Yu, Renxiao Wang*; Efficient Synthesis of Rottlerin and Its Two Subunits, Tetrahedron Lett. 2016, 57, 1856-1859.

7. Yangfeng Li, Biao Yu, Jiansong Song*, Renxiao Wang*; Efficient Synthesis of Baicalin and Its analogs, Tetrahedron Lett. 2015, 56, 3816-3819.