Zhen Wang

2014.08-2015.11, Postdoctoral Research Fellow, National University of Singapore (with Prof. Yixin Lu)

2009.09-2014.07, Ph.D in Organic Chemistry, College of Chemistry, Sichuan University (Supervisor: Prof. Xiaoming Feng)

2005.09-2009.07, B.S. in Chemistry, College of Chemistry, Sichuan University (Supervisor: Prof. Xiaoming Feng)

Asymmetric synthetic methodology

Active target-driven synthesis

Grants and fundings

National Natural Science Foundation of China (21602023)

Venture & Innovation Support Program for Chongqing Overseas Returnees (cx2019063)

The Fundamental Research Funds for the Central Universities (2020CDJQY-A042)

1.  Zongli Xiong, Jingxiang Duan, Xiaoyi Li, Xin Wang, Yesu Addepalli, Mengxue Lu, Weijun Yao, Ling He*, and Zhen Wang*. Palladium-Catalyzed Selective [2 + 2 + 2] Annulation of 2-(2-Enynyl)pyridines with Arynes. J. Org. Chem. 2021, 86, 12403–12411.

2.  Zhen Wang, Xiaohua Liu*, Xiaoming Feng*, “Asymmetric Catalysis Enabled by Chiral N,N'-Dioxide–Nickel(II) Complexes”, Aldrichimica Acta 2020, 53, 3.

3.  Xin Wang, Mengxue Lu, Qin Su, Minghui Zhou, Yesu Addepalli, Weijun Yao, Zhen Wang* and Yixin Lu*, “Phosphine-catalyzed [4+2] cycloadditions of allenic ketones: Enantioselective synthesis of functionalized tetrahydropyridines”, Chem. Asian J. 2019, 14, 3409-3413.

4.  Zhen Wang*, Yesu Addepalli, and Yun He*, “Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes”, Org. Lett. 2018, 20, 644.

5.  Yesu Addepalli, Xiaohong Yang, Minghui Zhou, D. Prabhakar Reddy, Shao-Lin Zhang, Zhen Wang* and Yun He*, “Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines”, Eur. J. Med. Chem. 2018, 151, 214.

6.  Minghui Zhou, Qin Su, Yesu Addepalli, Yun He* and Zhen Wang*, “An asymmetric Mannich reaction of α-diazocarbonyl compounds and N-sulfonyl cyclic ketimines catalyzed by complexes generated from chiral and achiral phosphines with gold(I)”, Org. Biomol. Chem. 2018, 16, 2923.

7.  Yesu Addepalli, Zhimei Yu, Jie Ji, Cheng Zou, Zhen Wang* and Yun He*, “Tandem Diels–Alder/oxidation–aromatization reactions involving 2-styrylchromones and arynes”, Org. Biomol. Chem. 2018, 16, 6077.

8.  Prabhakar Reddy, Ning Zhang, Zhimei Yu, Zhen Wang, Yun He*, “Total Synthesis of Kanamienamide”. J. Org. Chem., 2017, 82, 11262.

9.  Zhen Wang*, Tianli Wang, Weijun Yao and Yixin Lu* “Phosphine-Catalyzed Enantioselective [4 + 2] Annulation of o-Quinone Methides with Allene Ketones”, Org. Lett. 2017, 19, 4126.

10.  Zhen Wang*, Huacheng Xu, Qin Su, Ping Hu, Pan-Lin Shao, Yun He and Yixin Lu* “Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4+2]/[2+2] Cyclizations”, Org. Lett. 2017, 19, 3111.

11.  I. N. Chaithanya Kiran,† R. Santhosh Reddy,† Chandraiah Lagishetti, Huacheng Xu, Zhen Wang*, Yun He* “Selective Aza Diels-Alder and Domino [4+2]/[2+2] Cycloaddition Reactions of Arynes with N-Sulfonyl Ketimines”, J. Org. Chem. 2017, 82, 1823.

12.  Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili. Lin and Xiaoming Feng*, "Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N’-Dioxide–Metal Complexes" Angew. Chem. Int. Ed. 2012, 51, 2776.

13.  Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N’-Dioxide Complexes: Metal-Directed Switch in Enantioselectivity”, Angew. Chem. Int. Ed. 2011, 50, 4928.

14.  Zhen Wang, Tengfei Kang, Qian Yao, Jie Ji, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Scandium-Catalyzed Asymmetric 1,6-Addition of 3-Substituted Oxindoles to Linear Dienyl Ketones" Chem. Eur. J. 2015, 21, 7709.

15.  Zhen Wang, Zuliang Zhang, Qian Yao, Xiaohua Liu, Yunfei Cai, Lili Lin and Xiaoming Feng*, "Highly Stereoselective Conjugate Addition and α-Alkynylation Reaction with Electron-Deficient Alkynes Catalyzed by Chiral Scandium(III) Complexes" Chem. Eur. J. 2013, 19, 8591.

16.  Zhen Wang, Qian Yao, Tengfei Kang, Juhua Feng, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Highly Diastereo- and Enantioselective Michael Addition of 3-Substituted Benzofuran-2(3H)-ones to 4-Oxo-enoates Catalyzed by Lanthanide(III) Complexes" Chem. Comm., 2014, 50, 4918.

17.  Zhen Wang, Donghui Chen, Zhigang Yang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Synthesis of α-Stereogenic Esters through Catalytic Asymmetric Michael Addition of 4-Oxo-4-arylbutenoates" Chem. Eur. J. 2010, 16, 10130.

18.  Tengfei Kang, Zhen Wang, Lili Lin, Yuting Liao, Yuhang Zhou, Xiaohua Liu, and Xiaoming Feng* “N,N’-Dioxide/Zinc Bis(trifluoromethylsulfonyl)imide Complex Catalyzed Enantioselective Diels–Alder Reaction of Cyclopentadiene with Alkynones”, Adv. Synth. Catal. 2015, 357, 2045.

19.  Qian Yao, Zhen Wang, Yuheng Zhang, Xiaohua Liu, Lili Li, and Xiaoming Feng*, “N,N’-Dioxide/Gadolinium(III)-Catalyzed Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Pyrazolamides”, J. Org. Chem., 2015, 80, 5704.

20.  Sha Bai, Xiaohua Liu, Zhen Wang, Weidi Cao, Lili Lin and Xiaoming Feng*. "Catalytic Asymmetric Friedel–Crafts Reaction of Activated Phenols and 4-Oxo-4-arylbutenoates" Adv. Synth. Catal. 2012, 354, 2096–2100.

21.  Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)₃/N,N’-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives" Org. Lett., 2011, 13, 596-599.

22.  Donghui Chen, Zhen Wang, Jiangting Li, Zhigang Yang, Lili Lin, Xiaohua Liu and Xiaoming Feng*. "Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates: Highly Enantioselective Synthesis of Multisubstituted Isoxazolidines" Chem. Eur. J. 2011, 17, 5226 – 5229.

23.  Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex" Chem. Eur. J. 2010, 16, 6632 – 6637.

24.  Jie Liu, Zhigang Yang, Xiaohua Liu, Zhen Wang, Yanling Liu, Sha Bai, Lili Lin and Xiaoming Feng*. "Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine" Org. Biomol. Chem., 2009, 7, 4120–4127.

25.  Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins" Adv. Synth. Catal. 2008, 350, 2001 – 2006.

26.  Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine" J. Am. Chem. Soc. 2008, 130, 5654–5655.