Chuan-Rui Zhang

1999.09-2003.07, Beijing Normal University, majored in Applied Chemistry, B.S. (Supervisor: Academician Bo-Li Liu)

2003.09-2008.07, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, majored in Medicinal Chemistry, Ph.D. (Supervisor: Academician Jian-Min Yue)

2008.07-2010.10, Assistant Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

2010.10-2011.01, Associate Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

2011.01-2011.12, Postdoctoral Research Associate, SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona

2012.01-2015.12, Postdoctoral Research Associate, Bioactive Natural Products and Phytoceuticals Laboratory, Department of Horticulture, College of Agriculture & Natural Resources, Michigan State University

2016.07-present, Professor, School of Pharmaceutical Sciences, Chongqing University

Isolation and structure characterization of novel bioactive constituents from natural sources, including medicinal plants and fungi.

Discovery of drug leads and candidates from natural products.

Structural modification of bioactive natural compounds.

Awards:

2010 The first prize of Shanghai Municipal Award in natural science (Jian-Min Yue, Sheng-Ping Yang, Jian Ding, Chuan-Rui Zhang, Sheng Yin)

2009 The second prize of China Pharmaceutical Science and Technology Award (Jian-Min Yue, Sheng-Ping Yang, Jian Ding, Chuan-Rui Zhang, Sheng Yin)

2008 The first prize of Shanghai Pharmaceutical Science and Technology Award (Jian-Min Yue, Sheng-Ping Yang, Jian Ding, Chuan-Rui Zhang, Sheng Yin)

Grants and Fundings:

1.  National Natural Science Foundation of China, 22177016, 2022.01-2025.12

2.  State Key Laboratory of Phytochemistry and Plant Resources in West China (Kunming Institute of Botany, Chinese Academy of Sciences), P2020-KF09, 2020.11-2022.10

3.  Chongqing Research and Frontier Technology, cstc2020jcyj-jqX0009, 2020.07-2023.06

4.  The Fundamental Research Funds for the Central Universities, 2020CDJ-LHZZ-006, 2020.07-2023.06

5.  State Key Laboratory of Natural Medicines (China Pharmaceutical University), SKLNMKF202011, 2020.01-2021.12

6.  The Fundamental Research Funds for the Central Universities, 2020CDJQY-A078, 2020.01-2021.12

7.  Venture & Innovation Support Program for Chongqing Overseas Returnees, cx2018022, 2019.07-2020.12

8.  State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College), GTZK201901, 2019.05-2021.04

9.   State Key Laboratory of Drug Research (Shanghai Institute of Materia Medica, Chinese Academy of Sciences), SIMM1903KF-14, 2019.05-2020.04

10.  The Fundamental Research Funds for the Central Universities, 106112017CDJQJ468824, 2017.01-2018.12

11.  Start-Up Research Grant of Chongqing University, 2016.07-2022.06

12.  National Natural Science Foundation of China, 20932007, 2010.01-2013.12 (Co-PI: Guo-Lin Zhang, Chengdu Institute of Biology, Chinese Academy of Sciences)

13.  National Natural Science Foundation of China, 20902095, 2010.01-2012.12

1.  Yu-Xi Chen^#, Yun-Xia You^#, Li Rao^#, Yu Liu, Qian He, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Neolignans and sesquiterpenoid from Piper yunnanense. Chemistry & Biodiversity 2021, DOI: 10.1002/cbdv.202100458. (^#equal contribution)

2.  Qian He, Yue Fan, Yu Liu, Li Rao, Yun-Xia You, Yu Su, Zhen Zhou, You-Kai Xu, Chuan-Rui Zhang*. Cryptoyunnanones A‒H, complex flavanones from Cryptocarya yunnanensis. Journal of Natural Products 2021, 84, 2209−2216.

3.  Li Rao^#, Yao Li^#, Qian He, Yu Liu, Yu Su, Yun-Xia You, Yue Fan, Bin Lin, Yi-Nan Zhang, Chuan-Rui Zhang*. Iridoid constituents of Viburnum brachybotryum. Journal of Natural Products 2021, 84, 1915−1923. (^#equal contribution)

4.  Yu Liu, Yun-Xia You, Li Rao, Qian He, Yu Su, Yue Fan, Yizhou Li, You-Kai Xu, Chuan-Rui Zhang*. Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity. Chinese Journal of Natural Medicines Accepted.

5.  Qian He, Yue Fan, Yu Liu, Yun-Xia You, Li Rao, Yu Su, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Cytotoxic α-pyrone derivatives from Cryptocarya yunnanensis. Natural Product Research 2020, DOI: 10.1080/14786419.2020.1849205.

6.  Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Lignans and neolignans with antioxidant and human cancer cell proliferation inhibitory activities from Cinnamomum bejolghota confirm its functional food property. Journal of Agricultural and Food Chemistry 2020, 68, 8825−8835.

7.  Hong-Yan Xu, Ji-Hua Ren, Yu Su, Fang Ren, Yu-Jiao Zhou, Hui Jiang, Sheng-Tao Cheng, Chuan-Rui Zhang*, Juan Chen*. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim. Journal of Ethnopharmacology 2020, 257, 112787.

8.  Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang*. (±)-Meliviticines A and B: rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity. Bioorganic Chemistry 2019, 90, UNSP 103099.

9.  Yue Fan, Yu Liu, Yun-Xia You, Li Rao, Yu Su, Qian He, Feng Hu, Yizhou Li, Weili Wei, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Cytotoxic arylalkenyl α,β-unsaturated δ-lactones from Cryptocarya brachythyrsa. Fitoterapia 2019, 136, 104167.

10.  Li Rao, Yun-Xia You, Yu Su, Yu Liu, Qian He, Yue Fan, Feng Hu, You-Kai Xu, Chuan-Rui Zhang*. Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula. Fitoterapia 2019, 135, 5–8.

11.  Chuan-Rui Zhang, Wajid Khan, Jehan Bakht, Muraleedharan G. Nair*. New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit. Food Chemistry 2016, 196, 726-732.

12.  Chuan-Rui Zhang, Amila A. Dissanayake, Kudret Kevseroğlu, Muraleedharan G. Nair*. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chemistry 2015, 167, 24-29.

13.  Hua Zhang^#, Chuan-Rui Zhang^#, Ying-Shan Han, Mark A. Wainberg, Jian-Min Yue*. New Securinega alkaloids with anti-HIV activity from Flueggea virosa. RSC Advances 2015, 5, 107045-107053. (^#equal contribution)

14.  Chuan-Rui Zhang, Amila A. Dissanayake, Muraleedharan G. Nair*. Functional food property of honey locust (Gleditsia triacanthos) flowers. Journal of Functional Foods 2015, 18, 266-274.

15.  Chuan-Rui Zhang, Ettannil Jayashree, Paramasivam Suresh Kumar, Muraleedharan G. Nair*. Antioxidant and antiinflammatory compounds in nutmeg (Myristica fragrans) pericarp as determined by in vitro assays. Natural Product Communications 2015, 10, 1399-1402.

16.  Chuan-Rui Zhang, Saleh A. Aldosari, Polana S. P. V. Vidyasagar, Karun M. Nair, Muraleedharan G. Nair*. Antioxidant and anti-inflammatory assays confirm bioactive compounds in ajwa date fruit. Journal of Agricultural and Food Chemistry 2013, 61, 5834-5840.

17.  Chuan-Rui Zhang, Robert E. Schutzki, Muraleedharan G. Nair*. Antioxidant and anti-inflammatory compounds in the popular landscape plant Berberis thunbergii var. atropurpurea. Natural Product Communications 2013, 8, 165-168.

18.  Chuan-Rui Zhang, Hong-Bing Liu, Shi-Hui Dong, Yan Wu, Jian-Min Yue*. Alkaloids from the twigs and leaves of Daphniphyllum macropodum. Helvetica Chimica Acta 2013, 96, 499-504.

19.  Chuan-Rui Zhang^#, Cheng-Qi Fan^#, Shi-Hui Dong, Hong-Bing Liu, Wen-Bin Zhou, Yan Wu, Jian-Min Yue*. Angustimine and angustifolimine, two new alkaloids from Daphniphyllum angustifolium. Organic Letters 2011, 13, 2440-2443. (^#equal contribution)

20.  Chuan-Rui Zhang, Yan Wu, Jian-Min Yue*. Polyoxygenated seco-cyclohexene derivatives from Uvaria tonkinensis var. subglabra. Chinese Journal of Natural Medicines 2010, 8, 0084-0087.

21.  Chuan-Rui Zhang, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue*. Calycinumines A and B, two novel alkaloids from Daphniphyllum calycinum. Organic Letters 2009, 11, 4692-4695.

22.  Chuan-Rui Zhang, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue*. Alkaloids from the leaves of Daphniphyllum subverticillatum. Journal of Natural Products 2009, 72, 1669-1672.

23.  Chuan-Rui Zhang, Sheng-Ping Yang, Yan Wu, Xue-Qin Chen, Xue-Chu Zhen Jian-Min Yue*. Limonoids from the twigs and leaves of Chukrasia tabularis. Helvetica Chimica Acta 2008, 91, 2338-2350.

24.  Chuan-Rui Zhang, Sheng-Ping Yang, Yan Wu, Jian-Min Yue*. Alkaloids from the twigs of Daphniphyllum calycinum. Journal of Natural Products 2008, 71, 1663-1668.

25.  Chuan-Rui Zhang, Cheng-Qi Fan, Li Zhang, Sheng-Ping Yang, Yan Wu, Yang Lu, Jian-Min Yue*. Chuktabrins A and B, two novel limonoids from the twigs and leaves of Chukrasia tabularis. Organic Letters 2008, 10, 3183-3186.

26.  Chuan-Rui Zhang, Sheng-Ping Yang, Jian-Min Yue*. Sterols and triterpenoids from the spores of Ganoderma lucidum. Natural Product Research 2008, 22, 1137-1142.

27.  Chuan-Rui Zhang, Sheng-Ping Yang, Shang-Gao Liao, Cheng-Qi Fan, Yan Wu, Jian-Min Yue*. Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis. Organic Letters 2007, 9, 3383-3386.

28.  Chuan-Rui Zhang, Sheng-Ping Yang, Qiao Zhu, Shang-Gao Liao, Yan Wu, Jian-Min Yue. Nortriterpenoids from Chukrasia tabularis var. velutina. Journal of Natural Products 2007, 70, 1616-1619.

29.  Chuan-Rui Zhang, Sheng-Ping Yang, Shang-Gao Liao, Yan Wu, Jian-Min Yue*. Polyoxygenated cyclohexene derivatives from Uvaria rufa. Helvetica Chimica Acta 2006, 89, 1408-1416.