Gong Zhang

Title：Ph.D., Associate Professor

E-mail Address：gongzhang@cqu.edu.cn

Tel.：

Individual/Group Introduction

Group website of Yizhou Li Group:

https://www.x-mol.com/groups/li_yizhou

Education and Position

2020-now, Chongqing University, School of Pharmaceutical Sciences, Assistant Professor

2017-2020, Peking University, College of Chemistry and Molecular Engineering, Postdoctoral research associate, Supervisor: Prof. Peng R. Chen

2012-2017, Peking University, Academy for Advanced Interdisciplinary Studies, Ph.D., Supervisor: Prof. Peng R. Chen

2008-2012, Peking University, College of Life Sciences, B.S.

Research Interest

Medicinal Chemical Biology and Protein Chemical Biology

Including: 1) Novel selection strategies for DNA-encoded libraries (DELs); 2) Protein ligand discovery with pocket selectivity; 3) Selective modification on proteins and covalent inhibitor study.

Awards and Grants

Grants and Fundings

1. National Natural Science Foundation of China, General Program (22477011), 2025.01-2028.12

2. National Natural Science Foundation of China, Youth Program (22107016), 2022.01-2024.12

3. Chongqing Natural Science Foundation, General Program, 2022.01-2024.12

4. China Postdoctoral Science Foundation, General Program (2020M683251), 2020.11-2022.10

Representative articles

1. Zhang Gong, Zhang Juan, Gao Yuting, Li Yangfeng*, Li Yizhou*, Strategies for targeting undruggable targets, Expert Opinion on Drug Discovery, 2022, 17, 55-69.

2. Zhang Juan, Li Xianfeng, Wei Haimei, Li Yangfeng, Zhang Gong*, Li Yizhou*, Sequential DNA-encoded building block fusion for the construction of polysubstituted pyrazoline core libraries, Organic Letters, 2021, 23, 8429-8433

3. Zhu Rongfeng^#, Zhang Gong^#, Jing Miao, Han Yu, Li Jiaofeng, Li Yulong, Chen Peng R.*, Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction, Nature Communications, 2021, 12, 581.

4. Zhang Gong^#, Li Jie^#, Xie Ran, Fan Xinyuan, Liu Yanjun, Zheng Siqi, Ge Yun, Chen Peng R.*, Bioorthogonal chemical activation of kinases in living systems, ACS Central Science, 2016, 2, 325-331. (Highlighted by Chemical & Engineering News, 2016, 94(19), 5)

5. Zhang Gong^#, Zheng Siqi^#, Liu Haiping, Chen Peng R.*, Illuminating biological processes through site-specific protein labeling, Chemical Society Reviews, 2015, 44, 3405-3417.

6. Zheng Siqi^#, Zhang Gong^#, Li Jie, Chen Peng R.*, Monitoring endocytic trafficking of anthrax lethal factor by precise and quantitative protein labeling. Angewandte Chemie International Edition, 2014, 53, 6449-6453.