Jinqiang Zhang

Title：Ph.D., Associate Professor, PI

E-mail Address：j.zhang1983@cqu.edu.cn

Tel.：

Individual/Group Introduction: Our group’s research interests are the medicinal chemistry and chemical biology of bioactive peptide, and especially the clinical application of synthetic cyclic peptidomimetics. Currently, we’re focusing on the development of novel peptide drugs for the treatment of infectious diseases, cancer, cardiovascular diseases and diabetes.

Education and Position

2013.02-2016.01, Post-Doc, Departement de Chimie, Universite de Montreal. (Supervisor: William D. Lubell)

2008.12-2012.11, PhD, Department of Pharmaceutical Sciences, Utrecht University. (Supervisor: Rob Liskamp)

2006.09-2008.07, MSc, Department of Chemisty, Zhejiang University. (Supervisor: Feihe Huang)

2002.09-2006.07, BS, College of Chemistry and Chemical Engineering, Lanzhou University.

Research Interest

1) Development of Synthetic Strategy towards Macrocyclic Peptidomimetics.

2) Synthesis and Clinical Application of Macrocyclic Antimicrobial Peptides.

3) Synthesis and Clinical Application of Immuno-modulating Macrocyclic Peptides.

Awards and Grants

Grants and fundings

National Natural Science Foundation of China, Grant No. 22077013, 2021-2024.

National Natural Science Foundation of China, Grant No. 21602024, 2017-2019.

Representative articles

1. Chuan Dai, Fang Wang, Zhang, D.; Xu, L.; Xia, X. *; Zhang, J. *, Synthesis and Biological Evaluation of N‑Aminoimidazolidin-2-oneContaining Angiotensin-(1−7) Peptidomimetics, Org. Lett. 2020, 22, 8475-8479.

2. Proulx, C.; Zhang, J.; Sabatino, D.; Chemtob, S.; Ong, H.; Lubell, W.D. Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36). Biomedicines 2020, 8, 241. (Invited Review)

3. Li, H.; Hu, Y.; Pu, Q.; He, T.; Zhang, Q.; Wu, W.; Xia, X.;* Zhang. J.*, Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J. Med. Chem. 2020, 63, 4081-4089.

4. Dai, C.；Ma, J.；Li, M.；Wu, W.； Xia, X. *; Zhang, J. *, Diversity-Oriented Submonomer Synthesis of Azapeptides Mediated by Mitsunobu Reaction, Org. Chem. Front. 2019, 6, 2529-2533.

5. Zhang, J.; Mulumba, M.; Ong, H.; Lubell, W. D.*，Diversity-Oriented Synthesis of Cyclic Azapeptides by A3-Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics，Angew. Chem. Int. Ed. 2017, 56, 6284-6288.