王震

2015年11月－至今：重庆大学药学院（创新药物研究中心），专任教师/副教授；

2014年8月－2015年11月：新加坡国立大学，博士后，导师：Prof. Lu Yixin；

2009年9月－2014年7月：四川大学化学学院，理学博士，导师：冯小明院士；

2005年9月－2009年6月：四川大学化学学院，理学学士，导师：冯小明院士。

不对称合成方法学（有机催化/手性路易斯酸催化）

药物化学，生物活性化合物的合成研究

不对称催化是化学学科以及药物化学领域的前沿和研究热点，是获得光学活性化合物最高效的途径。王震博士长期从事有机合成和不对称催化工作，在手性金属配合物催化（主要是镧系路易斯酸金属催化，博士期间）以及有机小分子催化（手性氨基酸衍生的有机膦催化，博士后期间）等方面进行了系统的研究，取得了系列开拓性的创新成果。王震博士已在J. Am. Chem. Soc.，Angew.Chem. Int. Ed.，Chem. Commun.，Org. Lett.等国际权威刊物上发表论文多篇。

一、编写书籍、章节

(2) Xiaoming Feng*, Zhen Wang, Xiaohua Liu, Chiral Lewis Acid, “Chiral Lewis Acid Rare-Earth Metal Complexes in Enantioselective Catalysis”, Springer International Publishing AG, 2017, 147-192, DOI: 10.1007/3418_2017_1.

(1) Xiaoming Feng, Zhen Wang, Lili Lin, Electronic Encyclopedia of Reagents for Organic Synthesis, “1,3-Dicyclohexylcarbodiimide”, Wiley, 2017, 5-9.

二、论文发表

(25) Zhen Wang, Xiaohua Liu*, Xiaoming Feng*, “Asymmetric Catalysis Enabled by Chiral N,N'-Dioxide–Nickel(II) Complexes”, Aldrichimica Acta 2020, 53, 3.

(24) Xin Wang, Mengxue Lu, Qin Su, Minghui Zhou, Yesu Addepalli, Weijun Yao, Zhen Wang* and Yixin Lu*,“Phosphine-catalyzed [4+2] cycloadditions of allenic ketones: Enantioselective synthesis of functionalized tetrahydropyridines”, Chem. Asian J. 2019, 14, 3409-3413.

(23) Zhen Wang*, Yesu Addepalli, and Yun He*, “Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes”, Org. Lett. 2018, 20, 644.

(22) Yesu Addepalli, Xiaohong Yang, Minghui Zhou, D. Prabhakar Reddy, Shao-Lin Zhang, Zhen Wang* and Yun He*, “Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines”, Eur. J. Med. Chem. 2018, 151, 214.

(21) Minghui Zhou, Qin Su, Yesu Addepalli, Yun He* and Zhen Wang*, “An asymmetric Mannich reaction of α-diazocarbonyl compounds and N-sulfonyl cyclic ketimines catalyzed by complexes generated from chiral and achiral phosphines with gold(I)”, Org. Biomol. Chem. 2018, 16, 2923.

(20) Yesu Addepalli, Zhimei Yu, Jie Ji, Cheng Zou, Zhen Wang* and Yun He*, “Tandem Diels–Alder/oxidation–aromatization reactions involving 2-styrylchromones and arynes”, Org. Biomol. Chem. 2018, 16, 6077.

(19) Prabhakar Reddy, Ning Zhang, Zhimei Yu, Zhen Wang, Yun He*, “Total Synthesis of Kanamienamide”. J. Org. Chem., 2017, 82, 11262.

(18) Zhen Wang,* Tianli Wang, Weijun Yao and Yixin Lu* “Phosphine-Catalyzed Enantioselective [4 + 2] Annulation of o-Quinone Methides with Allene Ketones”, Org. Lett. 2017, 19, 4126.

(17) Zhen Wang*, Huacheng Xu, Qin Su, Ping Hu, Pan-Lin Shao, Yun He and Yixin Lu* “Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4+2]/[2+2] Cyclizations”, Org. Lett. 2017, 19, 3111.

(16) I. N. Chaithanya Kiran,† R. Santhosh Reddy,† Chandraiah Lagishetti, Huacheng Xu, Zhen Wang*, Yun He* “Selective Aza Diels-Alder and Domino [4+2]/[2+2] Cycloaddition Reactions of Arynes with N-Sulfonyl Ketimines”, J. Org. Chem. 2017, 82, 1823.

(15) Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili. Lin and Xiaoming Feng*, "Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N’-Dioxide–Metal Complexes" Angew. Chem. Int. Ed. 2012, 51, 2776.

(14) Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N’-Dioxide Complexes: Metal-Directed Switch in Enantioselectivity”, Angew. Chem. Int. Ed.2011, 50, 4928.

(13) Zhen Wang, Tengfei Kang, Qian Yao, Jie Ji, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Scandium-Catalyzed Asymmetric 1,6-Addition of 3-Substituted Oxindoles to Linear Dienyl Ketones" Chem. Eur. J. 2015, 21, 7709.

(12) Zhen Wang, Zuliang Zhang, Qian Yao, Xiaohua Liu, Yunfei Cai, Lili Lin and Xiaoming Feng*, "Highly Stereoselective Conjugate Addition and α-Alkynylation Reaction with Electron-Deficient Alkynes Catalyzed by Chiral Scandium(III) Complexes" Chem. Eur. J. 2013, 19, 8591.

(11) Zhen Wang, Qian Yao, Tengfei Kang, Juhua Feng, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Highly Diastereo- and Enantioselective Michael Addition of 3-Substituted Benzofuran-2(3H)-ones to 4-Oxo-enoates Catalyzed by Lanthanide(III) Complexes" Chem. Comm., 2014,50, 4918.

(10) Zhen Wang, Donghui Chen, Zhigang Yang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Synthesis of α-Stereogenic Esters through Catalytic Asymmetric Michael Addition of 4-Oxo-4-arylbutenoates" Chem. Eur. J. 2010, 16, 10130.

(9) Tengfei Kang, Zhen Wang, Lili Lin, Yuting Liao, Yuhang Zhou, Xiaohua Liu, and Xiaoming Feng* “N,N’-Dioxide/Zinc Bis(trifluoromethylsulfonyl)imide Complex Catalyzed Enantioselective Diels–Alder Reaction of Cyclopentadiene with Alkynones”, Adv. Synth. Catal. 2015, 357, 2045.

(8) Qian Yao, Zhen Wang, Yuheng Zhang, Xiaohua Liu, Lili Li, and Xiaoming Feng*, “N,N’-Dioxide/Gadolinium(III)-Catalyzed Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Pyrazolamides”, J. Org. Chem., 2015, 80, 5704.

(7) Sha Bai, Xiaohua Liu, Zhen Wang, Weidi Cao, Lili Lin and Xiaoming Feng*. "Catalytic Asymmetric Friedel–Crafts Reaction of Activated Phenols and 4-Oxo-4-arylbutenoates" Adv. Synth. Catal. 2012, 354, 2096–2100.

(6) Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)₃/N,N’-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives" Org. Lett., 2011, 13, 596-599.

(5) Donghui Chen, Zhen Wang, Jiangting Li, Zhigang Yang, Lili Lin, Xiaohua Liu and Xiaoming Feng*. "Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates: Highly Enantioselective Synthesis of Multisubstituted Isoxazolidines" Chem. Eur. J. 2011, 17, 5226 – 5229.

(4) Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex" Chem. Eur. J. 2010, 16, 6632 – 6637.

(3) Jie Liu, Zhigang Yang, Xiaohua Liu, Zhen Wang, Yanling Liu, Sha Bai, Lili Lin and Xiaoming Feng*. "Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine" Org. Biomol. Chem., 2009, 7, 4120–4127.

(2) Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins" Adv. Synth. Catal. 2008, 350, 2001 – 2006.

(1) Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine" J. Am. Chem. Soc. 2008, 130, 5654–5655.