张功

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张功

Title:副教授/硕士生导师

E-mail Address:gongzhang@cqu.edu.cn

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个人/团队介绍

药物化学生物学团队网站:https://www.x-mol.com/groups/li_yizhou

学习工作经历

2023.09-至今,   重庆大学,药学院(创新药物研究中心),副教授;

2020.09-2023.08,重庆大学,药学院(创新药物研究中心),弘深青年教师,助理研究员;

2017.07-2020.06,北京大学,化学与分子工程学院,博士后,合作导师:陈鹏教授;

2012.09-2017.07,北京大学,前沿交叉学科研究院,博士,导师:陈鹏教授;

2008.09-2012.07,北京大学,生命科学学院,学士;

研究领域

药物化学生物学,蛋白质化学生物学

DNA编码分子库(DNA-encoded library, DEL)的新型筛选技术研究;

蛋白质的位点特异性配体筛选策略研究;

蛋白质的选择性修饰与共价抑制剂研究。


项目成果

1.国家自然科学基金委青年项目(22107016),主持,2022.01-2024.12

2.重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0016),主持,2022.01-2024.12

3.中国博士后科学基金第68批面上资助(2020M683251),主持,2020.11-2022.10

代表性文章

1. Zhang Juan#; Liu Jinlu; Li Xianfeng; Ju Yunzhu; Li Yangfeng; Zhang Gong*; Li Yizhou*, Unexpected Cyclization Product Discovery from the Photoinduced Bioconjugation Chemistry between Tetrazole and Amine, Journal of the American Chemical Society, 2024, 146(3), 2122-2131

2. Zhang Gong, Zhang Juan, Gao Yuting, Li Yangfeng*, Li Yizhou*, Strategies for targeting undruggable targets, Expert Opinion on Drug Discovery, 2022, 17, 55-69.

3. Zhang Juan, Li Xianfeng, Wei Haimei, Li Yangfeng, Zhang Gong*, Li Yizhou*, Sequential DNA-encoded building block fusion for the construction of polysubstituted pyrazoline core libraries, Organic Letters, 2021, 23, 8429-8433

4. Zhu Rongfeng#, Zhang Gong#, Jing Miao, Han Yu, Li Jiaofeng, Li Yulong, Chen Peng R.*, Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction, Nature Communications, 2021, 12, 581.

5. Zhang Gong#, Li Jie#, Xie Ran, Fan Xinyuan, Liu Yanjun, Zheng Siqi, Ge Yun, Chen Peng R.*, Bioorthogonal chemical activation of kinases in living systems, ACS Central Science, 2016, 2, 325-331. (Highlighted by Chemical & Engineering News, 2016, 94(19), 5)

6. Zhang Gong#, Zheng Siqi#, Liu Haiping, Chen Peng R.*, Illuminating biological processes through site-specific protein labeling, Chemical Society Reviews, 2015, 44, 3405-3417.

7. Zheng Siqi#, Zhang Gong#, Li Jie, Chen Peng R.*, Monitoring endocytic trafficking of anthrax lethal factor by precise and quantitative protein labeling. Angewandte Chemie International Edition, 2014, 53, 6449-6453.